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Acknowledgements We thank Ina Primon Eliasen, Louise Kjerulf Christensen, Karin Hamborg Albrechtsen and Mette Hersom Bien for excellent technical assistance

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New mechanisms for weight loss are continually being explored, offering new potential drug targets from cannabinoid receptor blockers, nucleotide-binding domain, leucine-richcontaining family, pyrin domaincontaining-3 (NLRP3) inhibitors, free fatty acid receptor 2 (FFA2) inhibitors and gene-editing RNA therapy